منابع مشابه
Dna Damage Affecting Thyroidal Iodide Transport: an Explanation to Thyroid Stunning
III " Everything is possible but the impossible – just do it " 131 I is widely used clinically in the treatment of Graves´disease and differentiated thyroid cancer. However, cellular and molecular effects of 131 I irradiation in relation to absorbed dose are poorly documented. For instance, it is unknown what absorbed doses give rise to acute or delayed lethality, DNA damage that is fully resto...
متن کاملThyroidal iodide clearance and radioiodide uptake in protein-calorie malnutrition1
The thyroid function was evaluated in two comparable groups of 12 proteincalorie malnourished children respectively by oral and intravenous test using radioiodine 1311. Maximal radioiodide uptake (RAIUma5) peaked within 24 hr in the intravenously investigated children, but only after 48 hr in the orally investigated children. In both protein-calorie malnutrition groups, the mean RAIUmaX was sig...
متن کاملIodide transport and breast cancer.
Breast cancer is the second most common cancer worldwide and the leading cause of cancer death in women, with incidence rates that continue to rise. The heterogeneity of the disease makes breast cancer exceptionally difficult to treat, particularly for those patients with triple-negative disease. To address the therapeutic complexity of these tumours, new strategies for diagnosis and treatment ...
متن کاملIn vitro studies on the signal transduction of thyroidal uptake of 18F-FDG and 131I-Iodide.
UNLABELLED Glucose metabolism in radioiodine-negative metastases of differentiated thyroid carcinomas (DTC) may still be increased by thyroid-stimulating hormone (TSH) as demonstrated by PET with 18F-FDG. The mechanisms of signal transduction involved in that process are as yet not completely understood. Therefore, the aim of this study was to investigate the effects of TSH, of an analog of cyc...
متن کاملIodide Transport Defect and Breast Milk Iodine.
BACKGROUND Iodide transport defect (ITD) is a dyshormonogenetic congenital hypothyroidism caused by sodium/iodide symporter (NIS) gene mutations. In the lactating mammary gland, iodide is concentrated by NIS, and iodine for thyroid hormone synthesis is thereby supplied to the infant in the breast milk. CASE DESCRIPTION A 34-year-old Japanese woman was diagnosed with ITD caused by a homozygous...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1963
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)81344-8